HHS

FOA# Topic/Title Budget Deadline
NOT-MH-24-110 Notice of Special Interest (NOSI): SBIR/STTR Program Priorities to Bridge Gaps in Advancing the NIMH Mission N/A January 6, 2027
NOT-MH-24-120 Notice of Special Interest (NOSI): SBIR/STTR High-Priority Areas for Digital Mental Health Innovations N/A January 6, 2027
PAR-24-066 NEI Small Business Innovation Research (SBIR) Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U44-Clinical Trial Required) $2,000,000 September 23, 2026
PAS-22-196 Advancing Research on Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) $275,766 Phase I $1,838,436 Phase II September 6, 2025
RFA-DA-23-021 Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44 – Clinical Trial Optional) $320K,000 (Phase I); $2,500,000 (Phase II) February 15, 2025
NOT-NS-22-017 Notice of Special Interest: SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed) varies by mechanism January 7, 2025
NOT-DE-21-012 Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed) $259,613 for Phase I awards and $1,730,751 for Phase II awards September 5, 2025
PAR-21-226 Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R41/R42 Clinical Trial Not Allowed) $259,613 Phase I
$1,730,751 Phase II		 Janurary 6, 2025

DoE

FOA# TOPIC/TITLE BUDGET DEADLINE
Cradle-to-Commerce (C2C) N/A December 20, 2024
CDMRP Ovarian Cancer Research Program (OCRP) $300,000-2,000,000

Multiple Agencies

FOA# TOPIC/TITLE BUDGET DEADLINE
Sensor Technology for the 21st Century varies varies

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